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张永兰

时间:2022-06-02

编辑:冉秋月

张永兰简介



副教授,硕士生导师


教育背景:

2010/09 - 2015/06,重庆大学,化学工程与技术,博士,


工作简历:

2015年—至今   重庆理工大学ManBetX万博在线登录


教学与研究领域:

承担制药工程专业本科教学,从事代谢性疾病药物药理相关研究


发表论文:

Zhao WJ, Bian YP, Wang QH, Yin F, Yin L, Zhang YL, Liu JH, Blueberry-derived exosomes-like nanoparticles ameliorate nonalcoholic fatty liver disease by attenuating mitochondrial oxidative stress, 2021,1-14.

Hao YN,Shen SL,Yin F,Zhang YL,Liu JH,Unfolded protein response is involved in geniposide-regulating glucose-stimulated insulin secretion in INS-1 cells, Cell Biochemistry and Function, 2019, 37(5):368-376.

Cui HQ, Deng MS, Zhang YL, Yin F, Liu JH,Geniposide Increases Unfolded Protein Response-Mediating HRD1 Expression to Accelerate APP Degradation in Primary Cortical Neurons,Neurochemical Research, 2018, 43(3): 669-680.

Liu CY,Hao YN,Yin F,Zhang YL,Liu JH,Geniposide protects pancreatic beta cells from high glucose-mediated injury by activation of AMP-activated protein kinase,Cell Biology International, 2017, 41(5): 544-554.

Liu CY,Hao YN,Yin F,Zhang YL,Liu JH,Geniposide accelerates proteasome-degradation of Txnip to inhibit insulin secretion in pancreatic β cells,Journal of Endocrinological Investigation, 2017, 40(5): 505-512.

Gao D,Zhang YL,Yang FQ,Lin YX,Zhang QH,Xia ZN,In vitro Screening and Evaluation of 37 Traditional Chinese Medicines for Their Potential to Activate Peroxisome Proliferator‑activated Receptors‑γ,Pharmacognosy Magazine, 2016, 12(46): 120-127.

Hao YN,Liu CY,Yin F,Zhang YL,Liu JH,*5’-AMP-activated protein kinase plays an essential role ingeniposide-regulated glucose-stimulated insulin secretion in rat pancreaticINS-1 β cells Journal of Natural Medicines, 2016, 71(1): 123-130.

Gao D,Zhang YL,Yang FQ,Li F,Zhang QH,Xia ZN,The flower of Edgeworthia gardneri (wall.) Meisn. suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes,Journal of Ethnopharmacology,2016,191:379-386.

Zhang YL,Yin F,Liu JH,Liu ZX,Geniposide attenuates the phosphorylation of tau protein in cellular and APP/PS1 transgenic model of Alzheimer’s disease,Chemical Biology & Drug Design, 2016, 87: 409-418.

Gao D,Zhang YL,Xu P,Lin YX,Yang FQ,Liu JH,Zhu HW,Xia ZN,In vitro evaluation for PPARγ/β from the flower Edgeworthia gardneri(wall.)Meisn,Journal of Ethnopharmacology, 2015, 162: 14-19. Zhang YL,Xia ZN,Liu JH,Yin F,Cell signaling transduction mechanisms by which geniposide regulates insulin-degrading enzyme expression in primary cultured cortical neurons,CNS & Neurological Disorders-Drug Targets, 2015, 14(3): 370-377.

Zhang YL,Yin F,Liu JH,Liu ZX,Guo LX,Geniposide attenuated insulin-deficiency-induced acceleration of β-amyloidosis in the APP/PS1 transgenic model of Alzheimer’s disease,Neurochemistry International, 2015, 89: 7-16.

Liu JH,Liu ZX,Zhang YL,Yin F,A novel antagonistic role of natural compound icariin on neurotoxicity of amyloid β peptide,Indian Journal of Medical Research, 2015, 142(2): 190-195.

Zhang YL,Yin F,Liu JH,Wang YW,Geniposide protects pancreatic INS-1E β cells from hIAPP-induced cell,Cell Biology International, 2015, 39(4): 393-398.


教学及科研项目:

Txnip和GnT-IVa与京尼平苷调节葡萄糖转运体内吞的相关性研究,国家自然科学青年基金项目,在研

AMPK和Itch介导的Txnip降解与京尼平苷调节胰腺β细胞氧化还原的相关性研究,重庆市自然基金项目,在研


奖励及荣誉:

重庆理工大学“优秀班导师”,2020年

重庆市科学技术奖自然科学类二等奖(排名第四),《京尼平苷激活GLP-1受体的药理学机制研究》,2019年

重庆理工大学“就业工作先进个人”,2016年


联系方式lanzy2015@cqut.edu.cn



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